Research Activities
The L.R.S. Institute has rich clinical resources and is actively involved in research in the field of TB & Respiratory Diseases. In addition to indoor facilities the institute has a well developed outreach system of treating patients in the field conditions under supervision. The TB patients under the specified area of the Institute are being treated in the peripheral health centers (DOTS centers). At DOTS centers each patient is properly recorded till the full treatment. Sputum examinations are done at pre-defined intervals and recorded. Patients are given supervised treatment. The outcome of each patient is recorded. Home visits are done for patients who fail to turn up for treatment. This forms a very strong cohort group for any prospective research study.
The Institute assists the government of India in developing strategies for TB control and in implementation of the same. Based on operational research the faculty of the institute has contributed significantly to the development of national guidelines in India for management of tuberculosis, MDR-TB and pediatric tuberculosis under national programme.
The institute has Research Committee and Ethical Committee for evaluation of the research proposals. The Institute at present is having International / National collaboration. Several rapid diagnostic tests for the diagnosis of tuberculosis are already being field tested in collaboration with international agencies such as FIND (Foundation for Innovative Diagnostics). LRS Institute has already signed MOU with ICGEB (International Center for Genetic Engineering and Biotechnology).
The long-term goal of the institute will be to develop a center of excellence providing a platform for clinical immunological work in the field of tuberculosis and other respiratory diseases. The Research focus would be priority to work on the diagnosis, monitoring and evaluation of various newer therapeutic modalities like drugs and vaccines besides studying the immune pathogenesis and development of tuberculosis and other respiratory diseases. The institute will focus on the proteomics and genomics to achieve the above objectives. The facility will focus on discovering antigens, antibodies and immunological biomarkers for rapid and early diagnosis of tuberculosis, HIV-TB co-infection, MDR-TB and XDR-TB and on developing cost-effective devices for rapid detection of tuberculosis. This in a long run will help in the field evaluation and application of technology in tackling these diseases and will supplement the Revised National Tuberculosis Control Programme.
Ongoing research projects at LRS Institute of TB and Respiratory Diseases (2008-09):
S.no
Title
1.
Assessment of RNTCP Strategy and FNAC diagnosis (at 2 weeks) and 6 months duration of treatment for Peripheral Tubercular Lymphadenitis
Dr. D. Behera, Dr. J.K. Saini,Dr. Khalid U.K.,Dr. Kumud Gupta
2.
Identification of Biomarkers and Pathogen Regulated Targets for Tuberculosis Infection
Prof. V.S. Chauhan, Dr. D. Behera, Dr. Rupak Singla, Dr. Khalid
3.
Role of Suppressors of Cytokine Signaling (SOCS) during Mycrobacterial tuberculosis Infection
Dr.Krishnamurthy Natrajan, Dr. D. Behera, Dr. Rupak Singla
4.
A randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess Long Term (one-year) Efficacy and Safety of Tiotropium Inhalation Solution 5ug (2 puffs of 2.5ug) Delivered by the Respimat Inhaler in Patients with Chronic Obstructive Pulmonary Disease (COPD)
Dr. D. Behera
5.
Pentraxins and innate immunity to tuberculosis
Dr. P. Visalakshi
6.
Surveillance of drug resistance at LRSI TB & RD, New Delhi DOTS Area
Dr. P. Visalakshi
7.
Validation and clinical studies for Method for diagnosis of tuberculosis by smear microscopy, culture and polymerase chain reaction using processed clinical samples and kit thereof
Dr. P. Visalakshi
8.
To assess the feasibility of implementing liquid culture (MGIT) for early detection of MDR cases
Dr. D. Behera, Dr. P. Visalakshi, Dr. Rupak Singla
9.
To study the menstrual pattern of adolescent girls with pulmonary and extra pulmonary TB
Dr. Sangeeta Sharma
10.
To Study the HIV status of Paediatric and Extra-Pulmonary Tuberculosis patients
Dr. Sangeeta Sharma
11
To determine reasons for default and fate of defaulters under DOTS Plus
Dr. Rohit Sarin, Dr. Khalid UK, Dr. K. Mathuria, Sh. P.P. Sharma
12
To study profile of patients dying during DOTS Plus treatment and ascertain possible reasons
Dr. Rohit Sarin, Dr. Khalid UK,Dr. K. Mathuria, Sh. P.P. Sharma
13
A randomized placebo – controlled double blind trial comparing two treatment shortening regimens with the standard regimen (two months EHRZ followed by four months R,H) namely 1) two months Moxifloxacin,RHZ followed by two months Moxifloxacin, R, H
2) two months Moxifloxacin, followed by two months Moxifloxacin and R for the treatment of adults with pulmonary TB
Dr. Rupak Singla, Dr. D. Behera, Dr. Sanjay Gupta, Dr. J.K. Saini, Dr. Neeta Singla
14
Post treatment Sequele for MDR-TB patients under DOTS Plus
Dr. Neeta Singla ,Dr. D. Behera Dr. Rupak Singla
15
Profile of Tuberculosis among house hold contacts of MDR Tuberculosis registered under DOTS Plus
Dr. Neeta Singla, Dr. D. Behera, Dr. Rupak Singla, Dr. P. Visalakshi, Dr. Sandeep
16
Detection of somatic mutations on tyrosine kinase domain of epidermal growth factor receptor (EGFR) followed by mutant EGFR driven molecular mechanism in lung carcinoma
Dr. Matreyi S. Rajala, Dr. D. Behera, Dr. Anand Jaiswal, Dr. Kumud Gupta, Dr. R. K. Dewan
2008 DNB Thesis projects
S.no
Title
1.
To study profile of geriatric patients and their treatment outcome under DOTS
Dr. Mandeep Singh , Dr. Rohit Sarin, Dr. Neeta Singla, Dr. Khalid UK, Dr. Anil Jain
2.
To study the causes of mortality in tuberculosis patients
Dr. Sheikh Mohd. Suhail ,Dr. D. Behera, Dr. Sanjay Gupta
3.
Profile of patients failing to Category I or Category II treatment under RNTCP
Dr. Mir Faisal Majid, Dr. Rupak Singla, Dr. Neeta Singla, Dr. Vikram Vohra, Dr. P. Visalakshi
4.
Symptom based questionnaire to differentiate chronic obstructive pulmonary disease and asthma
Dr. Shweta Gupta , Dr. Lokendra Kumar, Dr. Sushil Munjal
5.
To determine the existence and the pattern of sleep disordered breathing in non-obese adult Indian snorers
Dr. Deepak Kumar ,Dr. Rajnish Gupta, Dr. Anand Jaiswal
6.
To assess the impact of endobronchial biopsy on the diagnosis of patients suspected with pulmonary sarcoidosis and its correlation with clinical, radiological and spirometry variables.
Dr. Uday A Gupta , Dr. S.B. Singh, Dr. M.M. Puri, Dr. A. Jaiswal, Dr. K. Gupta
Ongoing research projects at LRS Institute of TB and Respiratory Diseases (2009-10):
S.No
Title
1.
Study A4021016 Randomized open label, Phase III Trial of CP-751,871 in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non- small cell lung cancer
Prof. D. Behera, Dr. Jaiswal
2.
Respiratory problems in school children and air pollution
Dr. Somdatta Patra, Dr. KU Khalid
3.
School children and tobacco consumption
Dr. Somdatta Patra,Dr. KU Khalid
4.
Knowledge of tuberculosis and utilization of anti tuberculosis services in an urban slum of Delhi
Dr. Somdatta Patra, Dr. KU Khalid
5.
Study of factors contributing to non- compliance of DOTS among tuberculosis patients
Dr. KU Khalid, Mr. MS Ansari
6.
Species identification of Non Mycobacteria from patients with pulmonary and extra pulmonary tuberculosis
Dr. P. Visalakshi, Prof. D. Behera ,Dr. Jyoti Arora
7.
Molecular analysis of MDR and XDR strains of Mycobacterium tuberculosis isolated from a tertiary care hospital
Dr. P. Visalakshi, Dr. S. Mehrawal, Prof. D. Behera
8.
Utility of PCR for diagnosis of pulmonary and extra pulmonary TB in comparison with smear microscopy, conventional culture and MGIT 960 system.
Dr. Manpreet Bhalla, Dr. P. Visalakshi Prof. D. Behera
9.
Evaluation of Real time PCR for the diagnosis of PTB as well as EPTB specimens in comparison with conventional IS6110 PCR, MGIT 960 system, , conventional culture and smear microscopy
Dr. P. Visalakshi, Prof. D. Behera , Dr. Manpreet Bhalla
10.
Evaluation of DTB and CTB kits on the BD Probe Tec ET System
Prof. D. Behera, Dr. P. Visalakshi
11.
To study the impact of TB on HIV activity in dually infected patients using real time PCR assay.
Dr. Manpreet Bhalla, Dr. U.Agarwal
13.
To determine the frequency, risk factors and clinical profile of TB immune restoration disease in patients co-infected with HIV/TB receiving antiretroviral therapy .
Dr.Upasna.Agarwal, Dr. Amitabh Kumar, Pof. D. Behera
14.
Reference diagnostic range for serum immunoglobulin free light chains in Indian subjects comparison with multiple myeloma
Prof.(Dr.) D. Behera
15.
A randomised double blind, placebo-controlled study to evaluate the long-term safety and efficacy of Darbepoetin Alfa administered at 50 µg once-every-3-weeks to a hemoglobin ceiling of 12.0 g/dl in anemic subjects with advanced stage non-small cell lung cancer receiving multicycle chemotherapy
Prof.(Dr.) D. Behera
16.
To study the association of indoor environmental risk factors and childhood tuberculosis
Prof.(Dr.) D. Behera , Dr. Sangeeta Sharma, Dr. Somdatta Patra
17.
Studying the habit of tobacco consumption in persons working in L.R.S Institute of Tuberculosis and Respiratory Diseases
Dr. S.B. Singh, Dr. U.K. Khalid, Dr. Somdatta Patra
18.
To study occurrence of mycobacteremia in HIV infected patients with and without active tuberculosis
Dr. Upasna Agarwal, Dr. Amitabh Kumar, Dr.P. Visalakshi
19.
Evaluation of direct susceptibility protocol on MGIT as a multi centric trial
Dr. P. Visalakshi, Dr. J. Arora, Prof. (Dr.) D. Behera
20.
Evaluation of BD TB ID rapid Immunochromatographic kit for drug controller of India requirement
Dr. P. Visalakshi, Dr. Jyoti Arora, Prof. (Dr.) D. Behera
21.
Mycolic acid Antibody Real-Time Inhibition (MARTI) Serodiagnosis of TB
Prof. (Dr.) D. Behera
DNB Thesis projects (2009-10)
S.no
Title
1.
To determine blood lactate levels in patients with sepsis admitted to a respiratory intensive care unit and to correlate with their hospital outcomes
Dr. Amit Asati , Prof (Dr.) D. Behera, Dr. Rajnish Gupta
2
Comparative study of clinicoradiological profile of smokers and non smokers suffering from pulmonary tuberculosis
Dr. M.Laieq I. Haji , Dr. R. Sarin, Dr. Lokender Kumar
3.
Knowledge, Attitudes and Practices of HIV among new patients of tuberculosis attending a tertiary care TB Institute
Dr. Neeraj Bhushan ,Dr. Vikram Vohra, Dr. Upasna Agarwal, Dr. S. K. Munjal
4.
To study the effects of yoga on lung functions & quality of life in patients of COPD
Dr. Roseleen Bali, Dr. Sanjay Gupta , Dr. R. Singla ,Dr. J.K. Saini , Dr. I.V. Basavaraddi
5.
To compare the response of chemotherapeutic regimens (a) Cisplatin and docetaxel and (b) Cisplatin and irinotecan in appropriately staged IIIB/ IV cases of non small cell lung Cancer
Dr. Akshay Sahni , Dr. S.B. Singh ,Dr. Anand Jaiswal
6.
Study of risk behavior for HIV infection among tuberculosis patients
Dr. Ankur Gupta , Dr. S. K. Munjal ,Dr. R. Singla
7
To study the actual Direct Observation Treatment in patient receiving intensive phase of DOTS therapy and its association with treatment outcome under program condition
Dr. Sushil M. Kindo , Dr. M.M. Puri, Dr. R. Sarin ,Dr. Khalid. U. Khayyam
8.
To study aspergilloma in post tubercular patients presenting with hemoptysis
Dr. Sandeep Katiyar , Dr. A. K. Jain ,Dr. M.M. Puri, Dr. Anita Yadav ,Dr. Manpreet Bhalla
9.
To study the clinico-cytological and bacteriological correlation of cervical tubercular lymphadenitis.
Dr. Nameirakpam Shashikumar Singh , Dr. Rupak Singla, Dr. S.B. Singh, Dr. P. Visalakshi , Dr. Kumud Gupta
10.
To study clinical profile of extrapulmonary tuberculosis among HIV infected patients and assess the diagnostic yield of procedures performed
Dr. Manashree Mallick , Dr. Anand Jaiswal ,Dr. Upasna Agarwal, Prof. D. Behera